Tissue microsomes metabolism

Services: Metabolite ID, metabolic kinetics, Metabolism stability (half-life), Drug-Drug interaction etc

Species: Human, mouse, rat tissue microsomes

Enzymes: Liver, intestine, kidney, lung, and brain microsomes

In vitro metabolism studies using tissue microsomes and cultured cells are essential for understanding the metabolic pathways of drugs and their potential effects in vivo. These models allow researchers to investigate how drugs are metabolized by specific enzymes, providing insights into the formation of metabolites that can influence pharmacological activity and toxicity. By utilizing liver microsomes, for example, scientists can identify key metabolites and assess their kinetic properties, such as clearance rates and enzyme kinetics. This information is critical for predicting human metabolism and can guide drug development by highlighting potential metabolic issues early in the process.

At XLog, we specialize in in vitro metabolism studies using tissue microsomes and cultured cells, facilitating comprehensive metabolite identification and kinetic analyses. Our advanced methodologies enable us to provide detailed insights into drug metabolism, ensuring that our clients have the necessary data to optimize their drug candidates effectively.