Drug/metabolites Bioanalysis

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Assay: Drugs and metabolites quantification

Analytes: Small molecules, peptides, and protein absolute quantification

Sample type: In vitro and in vivo samples (blood, urine, feces, tissues)

Instrument: UPLC, LC-MS, and GC-MS

Assay development for quantifying drugs and their metabolites is a crucial step in pharmacokinetic studies, enabling researchers to assess the concentration of compounds in biological matrices accurately. Utilizing Ultra-Performance Liquid Chromatography (UPLC) allows for high-throughput analysis, facilitating the rapid processing of multiple samples while maintaining resolution and reliability. In contrast, Liquid Chromatography-Mass Spectrometry (LC-MS/MS) offers high sensitivity, enabling the detection of low-abundance metabolites and ensuring accurate quantification even in complex biological samples. Developing robust assays that combine these techniques not only streamlines the drug evaluation process but also enhances the understanding of pharmacodynamics and metabolism.

At XLog, we specialize in assay development using UPLC for high-throughput capabilities and LC-MS/MS for high sensitivity. Our expert team ensures that clients receive precise quantification of drugs and their metabolites, providing essential data to support drug development and regulatory submissions effectively.

Assay: Drugs and metabolites quantification

Analytes: Small molecules, peptides, and protein absolute quantification

Sample type: In vitro and in vivo samples (blood, urine, feces, tissues)

Instrument: UPLC, LC-MS, and GC-MS

Assay development for quantifying drugs and their metabolites is a crucial step in pharmacokinetic studies, enabling researchers to assess the concentration of compounds in biological matrices accurately. Utilizing Ultra-Performance Liquid Chromatography (UPLC) allows for high-throughput analysis, facilitating the rapid processing of multiple samples while maintaining resolution and reliability. In contrast, Liquid Chromatography-Mass Spectrometry (LC-MS/MS) offers high sensitivity, enabling the detection of low-abundance metabolites and ensuring accurate quantification even in complex biological samples. Developing robust assays that combine these techniques not only streamlines the drug evaluation process but also enhances the understanding of pharmacodynamics and metabolism.

At XLog, we specialize in assay development using UPLC for high-throughput capabilities and LC-MS/MS for high sensitivity. Our expert team ensures that clients receive precise quantification of drugs and their metabolites, providing essential data to support drug development and regulatory submissions effectively.

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