Innovating Health: Pharmaceuticals, Nutrition, and New Drugs
Our Services
Assay: Drugs and metabolites quantification
Analytes: Small molecules, peptides, and protein absolute quantification
Sample type: In vitro and in vivo samples (blood, urine, feces, tissues)
Instrument: UPLC, LC-MS, and GC-MS
Assay development for quantifying drugs and their metabolites is a crucial step in pharmacokinetic studies, enabling researchers to assess the concentration of compounds in biological matrices accurately. Utilizing Ultra-Performance Liquid Chromatography (UPLC) allows for high-throughput analysis, facilitating the rapid processing of multiple samples while maintaining resolution and reliability. In contrast, Liquid Chromatography-Mass Spectrometry (LC-MS/MS) offers high sensitivity, enabling the detection of low-abundance metabolites and ensuring accurate quantification even in complex biological samples. Developing robust assays that combine these techniques not only streamlines the drug evaluation process but also enhances the understanding of pharmacodynamics and metabolism.
At XLog, we specialize in assay development using UPLC for high-throughput capabilities and LC-MS/MS for high sensitivity. Our expert team ensures that clients receive precise quantification of drugs and their metabolites, providing essential data to support drug development and regulatory submissions effectively.
Test: Solubility, Chemical stability, LogP, Pka
Drugs: small molecules, peptides
Drug characterization is a fundamental aspect of pharmaceutical development, focusing on key properties such as solubility, Log P (partition coefficient), and stability. Solubility is critical for determining how well a drug can be absorbed in the gastrointestinal tract, directly influencing its bioavailability. The Log P value provides insight into a drug's lipophilicity and hydrophilicity, informing predictions about its permeability across biological membranes. Stability studies assess how a drug performs under various conditions, including temperature, pH, and light exposure, which is essential for ensuring product efficacy and safety over its shelf life. Understanding these characteristics not only aids in formulating effective drug delivery systems but also helps in identifying potential challenges early in the development process.
At XLog, we offer comprehensive drug characterization services, including solubility assessments, Log P determinations, dissociation constants (Pka), and stability evaluations. Our expertise ensures that clients receive thorough insights into their drug candidates, facilitating informed decision-making and optimizing formulations for successful therapeutic outcomes
Formulations: Co-solvent formulation, Cyclodextrin formulation, Dispersed formulation, Nanoparticle formulation, Micromulsion formulation, Targeted delivery formulation
Administration route: p.o., IV, IP, IM, IA, etc
Drug formulation is an important step in PK and PD studies, particularly for those with poor water solubility. Depending on the solubility properties of the active compounds, various formulation can be developed using lipids, surfactants, complexing agents, and co-solvents. These components work together to improve the dissolution of the drug in biological fluids, ultimately increasing its absorption. For initial animal testing, formulations such as suspensions or emulsions can be prepared to create stable and effective delivery systems for poorly soluble drugs. These formulations ensure that the drug can be administered in a usable form while maintaining its therapeutic efficacy.
At XLog, we specialize in developing optimized drug formulations tailored to the specific solubility characteristics of each candidate. Our expertise in formulating suspensions, emulsions, and other delivery systems ensures that clients are well-equipped for successful preclinical testing and further development.
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At [Pharmaceutical Company Name], we are dedicated to the advancement of healthcare through cutting-edge research and development. Our commitment to quality and innovation ensures that we deliver safe and effective solutions to meet the evolving needs of patients worldwide.
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